Presence of the Periodontal Bacterium Porphyromonas gingivalis in Patients With and Without Cancer: A Meta-analysis.
Keywords:microbiota, neoplasms, Porphyromonas gingivalis, periodontal bacteria
A high presence of periodontal pathogens such as Porphyromonas gingivalis (P. gingivalis) has been found in cancers at different body locations. The imbalance of the oral microbiome (dysbiosis) promotes the chronic inflammatory process that could contribute to carcinogenesis. To assess the P. gingivalis detection in cancer patients. A search for studies on P. gingivalis and neoplasms was conducted from 1974 to 2021 in the following databases: PubMed (MEDLINE), Cochrane Library, Web of Science (WoS), and Scopus. For dichotomous outcomes, the estimates of effects of an intervention were expressed as odds ratios (OR) using Mantel-Haenszel (M-H) method with 95% confidence intervals. Funnel plot and Egger’s test for publication bias analysis were used. Also, Newcastle-Ottawa (NOS) studies methodological quality assessment scale was employed. Thirteen studies that involved 1732 cancer patients and 3298 controls without cancer were included in this meta-analysis. P. gingivalis detection was 1.81 times more likely in cancer patients (p<0.01) compared to controls. P. gingivalis detection was also more likely in patients with colorectal (OR: 2.00, p=0.02) or pancreatic (OR: 1.32, p=0.02) tumors. In contrast, oral, esophageal, lung, or breast cancers did not show a significant increase of P. gingivalis detection (p>0.05).
Sun J, Tang Q, Yu S, Xie M, Xie Y, Chen G, et al. Role of the oral microbiota in cancer evolution and progression. Cancer Med. 2020;9(17):6306-6321.
Rajapriya P, Saravanan P, Burnice NK, Priyanka KC, Shalini S, Ramakrishnan R. Recent Advances in Salivary Proteomics, Genomics and Transcriptomics: A Reliable Tool in Periodontal diagnosis – A Review. Ann Dent UM. 2014;21(2):8-16.
Fujiwara N, Kitamura N, Yoshida K, Yamamoto T, Ozaki K, Kudo Y. Involvement of Fusobacterium Species in Oral Cancer Progression: A Literature Review Including Other Types of Cancer. Int J Mol Sci. 2020;21(17):6207.
Healy CM, Moran GP. The microbiome and oral cancer: More questions than answers. Oral Oncol. 2019;89:30-33.
Kakabadze MZ, Paresishvili T, Karalashvili L, Chakhunashvili D, Kakabadze Z. Oral microbiota and oral cancer: Review. Oncol Rev. 2020;14(2):476.
Wells G, Shea B, O’Connell D, Peterson J, Welch V, Losos M, Tugwell P. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses [Internet]. Ottawa (Canada): The Ottawa Hospital. Available from: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp
Kang M-S, Oh J-S, Kim H-J, Kim H-N, Lee I-K, Choi H-R, et al. Prevalence of oral microbes in the saliva of oncological patients. J Bact Virol. 2009;39(4):277-285.
Michaud DS, Izard J, Wilhelm-Benartzi CS, You DH, Grote VA, Tjønneland A, et al. Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study. Gut. 2013;62(12):1764-70.
Gao S, Li S, Ma Z, Liang S, Shan T, Zhang M, et al. Presence of Porphyromonas gingivalis in esophagus and its association with the clinicopathological characteristics and survival in patients with esophageal cancer. Infect Agent Cancer. 2016;11:3.
Mai X, Genco RJ, LaMonte MJ, Hovey KM, Freudenheim JL, Andrews CA, et al. Periodontal Pathogens and Risk of Incident Cancer in Postmenopausal Females: The Buffalo OsteoPerio Study. J Periodontol. 2016;87(3):257-67.
Fan X, Alekseyenko AV, Wu J, Peters BA, Jacobs EJ, Gapstur SM, et al. Human oral microbiome and prospective risk for pancreatic cancer: a population-based nested case-control study. Gut. 2017;67(1):120-127.
Peters BA, Wu J, Pei Z, Yang L, Purdue MP, Freedman ND, et al. Oral Microbiome Composition Reflects Prospective Risk for Esophageal Cancers. Cancer Res. 2017;77(23):6777-6787.
Yuan X, Liu Y, Kong J, Gu B, Qi Y, Wang X, et al. Different frequencies of Porphyromonas gingivalis infection in cancers of the upper digestive tract. Cancer Lett. 2017;404:1-7.
Chang C, Geng F, Shi X, Li Y, Zhang X, Zhao X, Pan Y. The prevalence rate of periodontal pathogens and its association with oral squamous cell carcinoma. Appl Microbiol Biotechnol. 2019;103(3):1393-1404.
Yang Y, Cai Q, Shu XO, Steinwandel MD, Blot WJ, Zheng W, et al. Prospective study of oral microbiome and colorectal cancer risk in low-income and African American populations. Int J Cancer. 2019;144(10):2381-2389.
Zhang L, Liu Y, Zheng HJ, Zhang CP. The Oral Microbiota May Have Influence on Oral Cancer. Front Cell Infect Microbiol. 2020;9:476.
Chen Q, Shao Z, Liu K, Zhou X, Wang L, Jiang E, et al. Salivary Porphyromonas gingivalis predicts outcome in oral squamous cell carcinomas: a cohort study. BMC Oral Health. 2021;21(1):228.
Wang X, Jia Y, Wen L, Mu W, Wu X, Liu T, et al. Porphyromonas gingivalis Promotes Colorectal Carcinoma by Activating the Hematopoietic NLRP3 Inflammasome. Cancer Res. 2021;81(10):2745-2759.
Petrick JL, Wilkinson JE, Michaud DS, Cai Q, Gerlovin H, Signorello LB, et al. The oral microbiome in relation to pancreatic cancer risk in African Americans. Br J Cancer. 2022;126(2):287-296.
Xiao L, Zhang Q, Peng Y, Wang D, Liu Y. The effect of periodontal bacteria infection on incidence and prognosis of cancer: A systematic review and meta-analysis. Medicine (Baltimore). 2020;99(15):e19698.
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