Langerhans Cell Histiocytosis: A Case Report And Update On Treatment Modalities

Authors

  • Firdaus Hanapiah Department of Oral & Maxillofacial Surgery, Eastman Dental Institute
  • Tun Muzamal Wildan Royal London Hospital, Dental Institute
  • Bashir M M Saeed Department of Oral & Maxillofacial Surgery, Eastman Dental Institute
  • Rusdi Abdul Rahman Department of Oral & Maxillofacial Surgery, Eastman Dental Institute

DOI:

https://doi.org/10.22452/adum.vol3no1.9

Keywords:

Langerhans cell histiocytosis, Letterer-Siwe disease, Birbeck's granules

Abstract

Various treatment modalities exist for Langerhans cell histiocytosis(LCH) due to its uncertain aetiology.. LCH patients are clinically divided into a single and multisystem group and each group warrants a different approach to treatment. However, histologically, CD Ia antigen and Birbeck's granules have been implicated in both types of the disease. This article therefore describes clinical presentations of different forms of the disease and the treatments contrived for them. The single system group is treated conservatively with either curettage of the localised lesion, intralesional steroid injection or in some cases radiotherapy. For the multisystem group, treatment consists of chemotherapeutic agents as either a single or combination therapy.

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Published

1996-12-31

Issue

Vol. 3 No. 1 (1996)

Section

Case Report

License

  1. The Faculty of Dentistry, Universiti Malaya holds the copyright of the published manuscript including all its components such as supplementary information, graphical contents and raw data without any restrictions.
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