Micro RNAs In Periodontal Disease – A Review

  • Mekha Grace Varghese Department of Periodontics, Pushpagiri College of Dental Sciences, Perumthuruthy, Thiruvalla, Kerala
  • Thomas George Valliaveettil Department of Periodontics, Pushpagiri College of Dental Sciences, Perumthuruthy, Thiruvalla, Kerala
  • Annie Kitty George Department of Periodontics, Pushpagiri College of Dental Sciences, Perumthuruthy, Thiruvalla, Kerala
  • Saranya Rajan Department of Periodontics, Pushpagiri College of Dental Sciences, Perumthuruthy, Thiruvalla, Kerala

Abstract

microRNAs (miRNAs) constitute a family of small, non-coding RNA molecules that regulate gene expression and protein expression. microRNAs have influence on a broad range of physiologic and pathologic conditions. They are also considered as promising biomarkers especially when they are secreted extracellularly. In the inflammatory pathways, they dysregulate the molecular processes and contribute to the development of chronic inflammatory diseases including periodontitis. In this review, we provide an overview of miRNA characteristics, biogenesis, mechanisms of action and profiling methods. In addition, the role of miRNAs in the pathobiology of periodontitis, especially those pertaining to the cellular and molecular pathways of inflammation has been considered to enhance our understanding of the pathobiology of periodontitis.

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Published
2020-04-21
How to Cite
VARGHESE, Mekha Grace et al. Micro RNAs In Periodontal Disease – A Review. Annals of Dentistry University of Malaya, [S.l.], v. 27, p. 11-21, apr. 2020. ISSN 2462-2060. Available at: <https://adum.um.edu.my/article/view/23473>. Date accessed: 06 july 2020.
Section
Review Article